Mizoribine for renal sarcoidosis: effective steroid tapering and prevention of recurrence
Identifieur interne : 001984 ( Main/Exploration ); précédent : 001983; suivant : 001985Mizoribine for renal sarcoidosis: effective steroid tapering and prevention of recurrence
Auteurs : Shuichi Ito [Japon] ; Tomonori Harada [Japon] ; Tomoko Nakamura [Japon] ; Tomoyuki Imagawa [Japon] ; Kiyotaka Nagahama [Japon] ; Takeshi Sasaki [Japon] ; Shuichiro Fujinaga [Japon] ; Yukoh Aihara [Japon] ; Shumpei Yokota [Japon]Source :
- Pediatric Nephrology [ 0931-041X ] ; 2009-02-01.
English descriptors
- KwdEn :
Abstract
Abstract: Sarcoidosis is a systemic disease of unknown etiology that is characterized by chronic non-caseating granulomatous inflammation with tissue destruction. It is an uncommon disease in children, and renal sarcoidosis in particular is very rare in adults and children. A 17-year-old boy with renal sarcoidosis was referred to our hospital with an initial diagnosis of pyelonephritis. Prior treatment with various antibiotics had not been effective, but tentative oral daily prednisolone (PSL) had partially ameliorated his symptoms, although the symptoms recurred during steroid tapering. We detected non-caseating granulomatous interstitial nephritis and numerous sclerotic glomeruli in a second biopsy specimen, compatible with the diagnosis of renal sarcoidosis. The patient was treated with pulsed methyl-prednisolone and oral daily doses of PSL and mizoribine (MZR). During the treatment with MZR, the PSL was successfully tapered, and the patient has since presented no signs of recurrence. Our treatment of this patient shows that treatment with MZR can allow steroid sparing and prevent recurrence in a patient with sarcoidosis.
Url:
DOI: 10.1007/s00467-008-0995-7
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001626
- to stream Istex, to step Curation: 001626
- to stream Istex, to step Checkpoint: 000889
- to stream Main, to step Merge: 001992
- to stream Main, to step Curation: 001984
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mizoribine for renal sarcoidosis: effective steroid tapering and prevention of recurrence</title><author><name sortKey="Ito, Shuichi" sort="Ito, Shuichi" uniqKey="Ito S" first="Shuichi" last="Ito">Shuichi Ito</name></author><author><name sortKey="Harada, Tomonori" sort="Harada, Tomonori" uniqKey="Harada T" first="Tomonori" last="Harada">Tomonori Harada</name></author><author><name sortKey="Nakamura, Tomoko" sort="Nakamura, Tomoko" uniqKey="Nakamura T" first="Tomoko" last="Nakamura">Tomoko Nakamura</name></author><author><name sortKey="Imagawa, Tomoyuki" sort="Imagawa, Tomoyuki" uniqKey="Imagawa T" first="Tomoyuki" last="Imagawa">Tomoyuki Imagawa</name></author><author><name sortKey="Nagahama, Kiyotaka" sort="Nagahama, Kiyotaka" uniqKey="Nagahama K" first="Kiyotaka" last="Nagahama">Kiyotaka Nagahama</name></author><author><name sortKey="Sasaki, Takeshi" sort="Sasaki, Takeshi" uniqKey="Sasaki T" first="Takeshi" last="Sasaki">Takeshi Sasaki</name></author><author><name sortKey="Fujinaga, Shuichiro" sort="Fujinaga, Shuichiro" uniqKey="Fujinaga S" first="Shuichiro" last="Fujinaga">Shuichiro Fujinaga</name></author><author><name sortKey="Aihara, Yukoh" sort="Aihara, Yukoh" uniqKey="Aihara Y" first="Yukoh" last="Aihara">Yukoh Aihara</name></author><author><name sortKey="Yokota, Shumpei" sort="Yokota, Shumpei" uniqKey="Yokota S" first="Shumpei" last="Yokota">Shumpei Yokota</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:79D1A040978CFB0C79F2D366FAEDDBA9861FF364</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1007/s00467-008-0995-7</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-0PKS5RV8-0/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001626</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001626</idno><idno type="wicri:Area/Istex/Curation">001626</idno><idno type="wicri:Area/Istex/Checkpoint">000889</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000889</idno><idno type="wicri:doubleKey">0931-041X:2008:Ito S:mizoribine:for:renal</idno><idno type="wicri:Area/Main/Merge">001992</idno><idno type="wicri:Area/Main/Curation">001984</idno><idno type="wicri:Area/Main/Exploration">001984</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Mizoribine for renal sarcoidosis: effective steroid tapering and prevention of recurrence</title><author><name sortKey="Ito, Shuichi" sort="Ito, Shuichi" uniqKey="Ito S" first="Shuichi" last="Ito">Shuichi Ito</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Children’s Medical Center, Yokohama City University Medical Center, 4–57, Urafune-cho, 232–0024, Minami-ku, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Japon</country></affiliation></author><author><name sortKey="Harada, Tomonori" sort="Harada, Tomonori" uniqKey="Harada T" first="Tomonori" last="Harada">Tomonori Harada</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Children’s Medical Center, Yokohama City University Medical Center, 4–57, Urafune-cho, 232–0024, Minami-ku, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Nakamura, Tomoko" sort="Nakamura, Tomoko" uniqKey="Nakamura T" first="Tomoko" last="Nakamura">Tomoko Nakamura</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Children’s Medical Center, Yokohama City University Medical Center, 4–57, Urafune-cho, 232–0024, Minami-ku, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Imagawa, Tomoyuki" sort="Imagawa, Tomoyuki" uniqKey="Imagawa T" first="Tomoyuki" last="Imagawa">Tomoyuki Imagawa</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Yokohama City University School of Medicine, Yokohama City University, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Nagahama, Kiyotaka" sort="Nagahama, Kiyotaka" uniqKey="Nagahama K" first="Kiyotaka" last="Nagahama">Kiyotaka Nagahama</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Yokohama City University Medical Center, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Sasaki, Takeshi" sort="Sasaki, Takeshi" uniqKey="Sasaki T" first="Takeshi" last="Sasaki">Takeshi Sasaki</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Yokohama City University Medical Center, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Fujinaga, Shuichiro" sort="Fujinaga, Shuichiro" uniqKey="Fujinaga S" first="Shuichiro" last="Fujinaga">Shuichiro Fujinaga</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Pediatric Nephrology, Saitama Children’s Medical Center, Iwatsuki, Saitama</wicri:regionArea><wicri:noRegion>Saitama</wicri:noRegion></affiliation></author><author><name sortKey="Aihara, Yukoh" sort="Aihara, Yukoh" uniqKey="Aihara Y" first="Yukoh" last="Aihara">Yukoh Aihara</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Children’s Medical Center, Yokohama City University Medical Center, 4–57, Urafune-cho, 232–0024, Minami-ku, Yokohama</wicri:regionArea><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Yokota, Shumpei" sort="Yokota, Shumpei" uniqKey="Yokota S" first="Shumpei" last="Yokota">Shumpei Yokota</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Pediatric Nephrology, Saitama Children’s Medical Center, Iwatsuki, Saitama</wicri:regionArea><wicri:noRegion>Saitama</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Pediatric Nephrology</title><title level="j" type="sub">Journal of the International Pediatric Nephrology Association</title><title level="j" type="abbrev">Pediatr Nephrol</title><idno type="ISSN">0931-041X</idno><idno type="eISSN">1432-198X</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2009-02-01">2009-02-01</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="411">411</biblScope><biblScope unit="page" to="414">414</biblScope></imprint><idno type="ISSN">0931-041X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0931-041X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Children</term><term>Granulomatous interstitial nephritis</term><term>Mizoribine</term><term>Prednisolone</term><term>Renal</term><term>Sarcoidosis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Sarcoidosis is a systemic disease of unknown etiology that is characterized by chronic non-caseating granulomatous inflammation with tissue destruction. It is an uncommon disease in children, and renal sarcoidosis in particular is very rare in adults and children. A 17-year-old boy with renal sarcoidosis was referred to our hospital with an initial diagnosis of pyelonephritis. Prior treatment with various antibiotics had not been effective, but tentative oral daily prednisolone (PSL) had partially ameliorated his symptoms, although the symptoms recurred during steroid tapering. We detected non-caseating granulomatous interstitial nephritis and numerous sclerotic glomeruli in a second biopsy specimen, compatible with the diagnosis of renal sarcoidosis. The patient was treated with pulsed methyl-prednisolone and oral daily doses of PSL and mizoribine (MZR). During the treatment with MZR, the PSL was successfully tapered, and the patient has since presented no signs of recurrence. Our treatment of this patient shows that treatment with MZR can allow steroid sparing and prevent recurrence in a patient with sarcoidosis.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Ito, Shuichi" sort="Ito, Shuichi" uniqKey="Ito S" first="Shuichi" last="Ito">Shuichi Ito</name></noRegion><name sortKey="Aihara, Yukoh" sort="Aihara, Yukoh" uniqKey="Aihara Y" first="Yukoh" last="Aihara">Yukoh Aihara</name><name sortKey="Fujinaga, Shuichiro" sort="Fujinaga, Shuichiro" uniqKey="Fujinaga S" first="Shuichiro" last="Fujinaga">Shuichiro Fujinaga</name><name sortKey="Harada, Tomonori" sort="Harada, Tomonori" uniqKey="Harada T" first="Tomonori" last="Harada">Tomonori Harada</name><name sortKey="Imagawa, Tomoyuki" sort="Imagawa, Tomoyuki" uniqKey="Imagawa T" first="Tomoyuki" last="Imagawa">Tomoyuki Imagawa</name><name sortKey="Ito, Shuichi" sort="Ito, Shuichi" uniqKey="Ito S" first="Shuichi" last="Ito">Shuichi Ito</name><name sortKey="Nagahama, Kiyotaka" sort="Nagahama, Kiyotaka" uniqKey="Nagahama K" first="Kiyotaka" last="Nagahama">Kiyotaka Nagahama</name><name sortKey="Nakamura, Tomoko" sort="Nakamura, Tomoko" uniqKey="Nakamura T" first="Tomoko" last="Nakamura">Tomoko Nakamura</name><name sortKey="Sasaki, Takeshi" sort="Sasaki, Takeshi" uniqKey="Sasaki T" first="Takeshi" last="Sasaki">Takeshi Sasaki</name><name sortKey="Yokota, Shumpei" sort="Yokota, Shumpei" uniqKey="Yokota S" first="Shumpei" last="Yokota">Shumpei Yokota</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001984 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001984 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:79D1A040978CFB0C79F2D366FAEDDBA9861FF364
|texte= Mizoribine for renal sarcoidosis: effective steroid tapering and prevention of recurrence
}}
| This area was generated with Dilib version V0.6.33. |  |